In Of Mice and Men, what trouble did George and Lennie have in Weed? Can be found in chapter one of the book.

Weed is
a small town located in Siskiyou County in the extreme northwest of California, not far from the
Oregon border.andfirst appear in the Salinas Valley. They have traveled hundreds of miles and
may have been so unnerved by their near-death experience in Weed that they wanted to get as far
away from the area as possible before lookinig for work.

The repeated
references to the incident in Weed suggest that something of great importance to the story
occurred there. Supposedly Lennie only wanted to feel a girl's dress, and she took it to have
been something much more sinister. But when Lennie kills Curley's wife in the barn, George
realizes that Lennie is changing. George, unlike the reader, does not understand exactly how
Lennie came to kill Curley's wife, but it looks as though it involved sexual assault--which is
exactly what it could have turned into if the girl hadn't put up a struggle and gotten her neck
broken. And perhaps the girl in Weed might also have been sexually assaulted if she hadn't
screamed and attracted a bunch of men.

When looking at the body of Curley's
wife, half covered with hay, George says hopelessly, "I should have knew. I guess maybe way
back in my head I did." What George should have known was that Lennie is changing. He is
developing an ominous interest in the opposite sex, an interest he doesn't understand and cannot
control.

It is a combination of two events, the one in Weed and the one at
the ranch, that make George decide to kill his friend. George feels that Lennie has become a
threat to society, and he feels personally guilty for the death of Curley's wife because he
should have known that Lennie was potentially dangerous. The incident in Weed, which nearly cost
George his own life, should have been a wake-up signal, but he let himself believe Lennie
"meant no harm."