Which group suffered most from European colonization of the Western hemisphere: Native Americans or enslaved Africans?

Both
Native Americans and Africans suffered at the hands of European colonizers. When we consider the
question of who suffered more, it's important to understand perspectives.
 In my answer, I'll look at a variety of perspectives and compare the impact of European
colonization on both groups.

Social

The most immediate answer as to which group suffered more would be... well, both.  But
if we look at the Caste System (la Sociedad de las Castas), I would argue that enslaved Africans
were most negatively impacted by European colonies in the New World.  When colonies were
created, Europeans brought with them a social system that organized the inhabitants (both free
and enslaved) based on the percentage of European blood in them, or "whiteness."  At
the top of the caste system were the Europeans, both Spanish/Portuguese born as well as
Europeans born in the New World.  Underneath those Europeans were the mixed races, with
preference to mixes that had higher percentages of "whiteness."...